Altered sensorimotor integration in Parkinson’s disease
Identifieur interne : 001941 ( Main/Exploration ); précédent : 001940; suivant : 001942Altered sensorimotor integration in Parkinson’s disease
Auteurs : Gwyn N. Lewis [Nouvelle-Zélande] ; Winston D. Byblow [Nouvelle-Zélande]Source :
- Brain [ 0006-8950 ] ; 2002-09.
English descriptors
- KwdEn :
- Abbreviations: ECR = extensor carpi radialis; FCR = flexor carpi radialis; ICI = intracortical inhibition; ISI = interstimulus interval; MEP = motor evoked potential; r.m.s. = root mean square; RTh = rest threshold; TES = transcranial electrical stimulation; TMS = transcranial magnetic stimulation, Keywords: Parkinson’s disease; sensorimotor integration; transcranial magnetic stimulation; Ia afferent; intracortical inhibition.
Abstract
Transcranial magnetic stimulation (TMS) was used to investigate sensorimotor integration in the upper limb of 10 patients with Parkinson’s disease and 10 age‐matched controls. Non‐conditioned and subthreshold conditioned (2 ms interstimulus interval) responses were recorded in the flexor and extensor carpi radialis muscles (FCR and ECR) of the more impaired (non‐dominant) limb. Stimuli were delivered while the wrist joint was positioned statically at various joint angles as well as during different phases of passive movement of the wrist joint (90° amplitude, 0.2 Hz). The FCR and ECR muscles remained relaxed during all stimulation. In both groups, responses in the static condition were larger when the target muscle was in a shortened position. Responses were also facilitated in the muscle shortening phases of passive movement. In both static and dynamic conditions, the extent of modulations in response amplitude was significantly reduced in the patient group. The level of intracortical inhibition (ICI) was also significantly less in the Parkinson’s disease patients in static conditions. During passive movement, control subjects demonstrated a clear reduction in ICI compared with the static trials; however, the level of ICI was unchanged in the Parkinson’s disease group in the dynamic condition. The results suggest an abnormal influence of afference on corticomotor excitability in Parkinson’s disease. This may be related to abnormal sensory input, a defective integrative unit or an inappropriate motor response.
Url:
DOI: 10.1093/brain/awf200
Affiliations:
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Byblow</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:653462B6F5B131E7C3F2DE8DAF82896D52DE6945</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1093/brain/awf200</idno><idno type="url">https://api.istex.fr/document/653462B6F5B131E7C3F2DE8DAF82896D52DE6945/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002A54</idno><idno type="wicri:Area/Main/Curation">002696</idno><idno type="wicri:Area/Main/Exploration">001941</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Altered sensorimotor integration in Parkinson’s disease</title><author><name sortKey="Lewis, Gwyn N" sort="Lewis, Gwyn N" uniqKey="Lewis G" first="Gwyn N." last="Lewis">Gwyn N. Lewis</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Human Motor Control Laboratory, Department of Sport and Exercise Science, University of Auckland</wicri:regionArea><wicri:noRegion>University of Auckland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Human Motor Control Laboratory, Department of Sport and Exercise Science, University of Auckland</wicri:regionArea><wicri:noRegion>University of Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Byblow, Winston D" sort="Byblow, Winston D" uniqKey="Byblow W" first="Winston D." last="Byblow">Winston D. Byblow</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Human Motor Control Laboratory, Department of Sport and Exercise Science, University of Auckland</wicri:regionArea><wicri:noRegion>University of Auckland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Human Motor Control Laboratory, Department of Sport and Exercise Science, University of Auckland</wicri:regionArea><wicri:noRegion>University of Auckland</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><title level="j" type="abbrev">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2002-09">2002-09</date><biblScope unit="volume">125</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="2089">2089</biblScope><biblScope unit="page" to="2099">2099</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">653462B6F5B131E7C3F2DE8DAF82896D52DE6945</idno><idno type="DOI">10.1093/brain/awf200</idno><idno type="local">awf200</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abbreviations: ECR = extensor carpi radialis; FCR = flexor carpi radialis; ICI = intracortical inhibition; ISI = interstimulus interval; MEP = motor evoked potential; r.m.s. = root mean square; RTh = rest threshold; TES = transcranial electrical stimulation; TMS = transcranial magnetic stimulation</term><term>Keywords: Parkinson’s disease; sensorimotor integration; transcranial magnetic stimulation; Ia afferent; intracortical inhibition</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Transcranial magnetic stimulation (TMS) was used to investigate sensorimotor integration in the upper limb of 10 patients with Parkinson’s disease and 10 age‐matched controls. Non‐conditioned and subthreshold conditioned (2 ms interstimulus interval) responses were recorded in the flexor and extensor carpi radialis muscles (FCR and ECR) of the more impaired (non‐dominant) limb. Stimuli were delivered while the wrist joint was positioned statically at various joint angles as well as during different phases of passive movement of the wrist joint (90° amplitude, 0.2 Hz). The FCR and ECR muscles remained relaxed during all stimulation. In both groups, responses in the static condition were larger when the target muscle was in a shortened position. Responses were also facilitated in the muscle shortening phases of passive movement. In both static and dynamic conditions, the extent of modulations in response amplitude was significantly reduced in the patient group. The level of intracortical inhibition (ICI) was also significantly less in the Parkinson’s disease patients in static conditions. During passive movement, control subjects demonstrated a clear reduction in ICI compared with the static trials; however, the level of ICI was unchanged in the Parkinson’s disease group in the dynamic condition. The results suggest an abnormal influence of afference on corticomotor excitability in Parkinson’s disease. This may be related to abnormal sensory input, a defective integrative unit or an inappropriate motor response.</div></front></TEI><affiliations><list><country><li>Nouvelle-Zélande</li></country></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Lewis, Gwyn N" sort="Lewis, Gwyn N" uniqKey="Lewis G" first="Gwyn N." last="Lewis">Gwyn N. Lewis</name></noRegion><name sortKey="Byblow, Winston D" sort="Byblow, Winston D" uniqKey="Byblow W" first="Winston D." last="Byblow">Winston D. Byblow</name><name sortKey="Byblow, Winston D" sort="Byblow, Winston D" uniqKey="Byblow W" first="Winston D." last="Byblow">Winston D. Byblow</name><name sortKey="Lewis, Gwyn N" sort="Lewis, Gwyn N" uniqKey="Lewis G" first="Gwyn N." last="Lewis">Gwyn N. Lewis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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